913 research outputs found
The Principal Optical PolarisabiIities of the Naphthalene Molecule
This paper deals with the principal optical polarisability of the Naphthalene Molecules@IAC
Evolutionary multiobjective optimization of the multi-location transshipment problem
We consider a multi-location inventory system where inventory choices at each
location are centrally coordinated. Lateral transshipments are allowed as
recourse actions within the same echelon in the inventory system to reduce
costs and improve service level. However, this transshipment process usually
causes undesirable lead times. In this paper, we propose a multiobjective model
of the multi-location transshipment problem which addresses optimizing three
conflicting objectives: (1) minimizing the aggregate expected cost, (2)
maximizing the expected fill rate, and (3) minimizing the expected
transshipment lead times. We apply an evolutionary multiobjective optimization
approach using the strength Pareto evolutionary algorithm (SPEA2), to
approximate the optimal Pareto front. Simulation with a wide choice of model
parameters shows the different trades-off between the conflicting objectives
Mean Dietary Salt Intake in Urban and Rural Areas in India: A Population Survey of 1395 Persons.
BACKGROUND: The scientific evidence base in support of population-wide salt reduction is strong, but current high-quality data about salt intake levels in India are mostly absent. This project sought to estimate daily salt consumption levels in selected communities of Delhi and Haryana in north India and Andhra Pradesh in south India. METHODS AND RESULTS: In this study, 24-hour urine samples were collected using an age- and sex-stratified sampling strategy in rural, urban, and slum areas. Salt intake estimates were made for the overall population of each region and for major subgroups by weighting the survey data for the populations of Delhi and Haryana, and Andhra Pradesh. Complete 24-hour urine samples were available for 637 participants from Delhi and Haryana and 758 from Andhra Pradesh (65% and 68% response rates, respectively). Weighted mean population 24-hour urine excretion of salt was 8.59 g/day (95% CI 7.68-9.51) in Delhi and Haryana and 9.46 g/day (95% CI 9.06-9.85) in Andhra Pradesh (P=0.097). Estimates inflated to account for the minimum likely nonurinary losses of sodium provided corresponding estimates of daily salt intake of 9.45 g/day (95% CI 8.45-10.46) and 10.41 g/day (95% CI 9.97-10.84), respectively. CONCLUSIONS: Salt consumption in India is high, with mean population intake well above the World Health Organization recommended maximum of 5 g/day. A national salt reduction program would likely avert much premature death and disability
Vortices in (2+1)d Conformal Fluids
We study isolated, stationary, axially symmetric vortex solutions in
(2+1)-dimensional viscous conformal fluids. The equations describing them can
be brought to the form of three coupled first order ODEs for the radial and
rotational velocities and the temperature. They have a rich space of solutions
characterized by the radial energy and angular momentum fluxes. We do a
detailed study of the phases in the one-parameter family of solutions with no
energy flux. This parameter is the product of the asymptotic vorticity and
temperature. When it is large, the radial fluid velocity reaches the speed of
light at a finite inner radius. When it is below a critical value, the velocity
is everywhere bounded, but at the origin there is a discontinuity. We comment
on turbulence, potential gravity duals, non-viscous limits and non-relativistic
limits.Comment: 39 pages, 10 eps figures, v2: Minor changes, refs, preprint numbe
Mean Dietary Salt Intake in Urban and Rural Areas in India: A Population Survey of 1395 Persons
This work was supported by a funding award made by the Global
Alliance for Chronic Disease through the National Health and
Medical Research Council of Australia (APP1040179). Johnson
is supported by a National Health and Medical Research Council
Postgraduate Scholarship (APP1074678). Webster is supported
by a National Health and Medical Research Council/
National Heart Foundation Career Development Fellowship
(APP1082924). Neal is supported by a National Health and
Medical Research Council of Australia Principal Research
Fellowship (APP1106947). He also holds an NHMRC Program
Grant (APP1052555). Maulik is an Intermediate Career Fellow
of the WT/DBT India Alliance. Shivashankar is supported by a
Wellcome Trust Capacity Strengthening Strategic Award
Extension Phase to the Public Health Foundation of India and
a consortium of UK universities (WT084754/Z/08/A)
A Lipid Based Antigen Delivery System Efficiently Facilitates MHC Class-I Antigen Presentation in Dendritic Cells to Stimulate CD8+ T Cells
The most effective strategy for protection against intracellular infections such as Leishmania is
vaccination with live parasites. Use of recombinant proteins avoids the risks associated with live
vaccines. However, due to low immunogenicity, they fail to trigger T cell responses particularly of CD8+cells requisite for persistent immunity. Previously we showed the importance of protein entrapment in cationic liposomes and MPL as adjuvant for elicitation of CD4+ and CD8+ T cell responses for longterm protection. In this study we investigated the role of cationic liposomes on maturation and antigen presentation capacity of dendritic cells (DCs). We observed that cationic liposomes were taken up very
efficiently by DCs and transported to different cellular sites. DCs activated with liposomal rgp63 led to
efficient presentation of antigen to specific CD4+ and CD8+ T cells. Furthermore, lymphoid CD8+ T cells from liposomal rgp63 immunized mice demonstrated better proliferative ability when co-cultured ex vivo with stimulated DCs. Addition of MPL to vaccine enhanced the antigen presentation by DCs and induced more efficient antigen specific CD8+ T cell responses when compared to free and liposomal ntigen. These liposomal formulations presented to CD8+ T cells through TAP-dependent MHC-I pathway offer new possibilities for a safe subunit vaccine
Higher spin extension of cosmological spacetimes in 3D: asymptotically flat behaviour with chemical potentials and thermodynamics
A generalized set of asymptotic conditions for higher spin gravity without
cosmological constant in three spacetime dimensions is constructed. They
include the most general temporal components of the gauge fields that
manifestly preserve the original asymptotic higher spin extension of the
BMS algebra, with the same central charge. By virtue of a suitable
permissible gauge choice, it is shown that this set can be directly recovered
as a limit of the boundary conditions that have been recently constructed in
the case of negative cosmological constant, whose asymptotic symmetries are
spanned by two copies of the centrally-extended W algebra. Since the
generalized asymptotic conditions allow to incorporate chemical potentials
conjugated to the higher spin charges, a higher spin extension of locally flat
cosmological spacetimes becomes naturally included within the set. It is shown
that their thermodynamic properties can be successfully obtained exclusively in
terms of gauge fields and the topology of the Euclidean manifold, which is
shown to be the one of a solid torus, but with reversed orientation as compared
with one of the black holes. It is also worth highlighting that regularity of
the fields can be ensured through a procedure that does not require an explicit
matrix representation of the entire gauge group. In few words, we show that the
temporal components of generalized dreibeins can be consistently gauged away,
which partially fixes the chemical potentials, so that the remaining conditions
can just be obtained by requiring the holonomy of the generalized spin
connection along a thermal circle to be trivial. The extension of the
generalized asymptotically flat behaviour to the case of spins is also
discussed.Comment: 33 pages, one figure. Talk given at the "Meeting on the horizon",
Valparaiso, Chile, March 201
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